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Growing evidences and real-world changes convincingly show that humanity is driving the global environmental change and pushing the world in to the widely claimed new geological epoch- the “Anthropocene” and trigger the anthropogenic crisis across the globe. In fact we are in the middle of environmental, economic and social crises having enormous repercussions on “Biosustainability” due to various destructive agents such as environmental contamination through dumping of solid wastes, chemical pollutants, hither-to unknown health issues, climate change, rapid biodiversity loss, interferences with biogeochemical cycles, stratospheric ozone depletion, ocean acidification, declining global freshwater reserve, change in land use pattern, loading of atmosphere with aerosol, rapid rise in green house impact and many other detrimental tools of mass destruction in a multidisciplinary approach.It would also facilitate a better understanding of the underlying scientific process towards Biosustainability under the ongoing global climate change.