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With today’s complex global supply chain where products transported from distant origin to destination passing through different points along with the increased pressure from regulators to ensure the quality and safety of products; it is mandatory for pharmaceutical, drug distributors and pharmacists to understand the best practices for distribution, packaging, security and storage of temperature sensitive products to cope with the numerous challenges that they face. This is especially important to Saudi Arabia as most temperature-sensitive pharmaceuticals are imported and because the kingdom is very big, and medicines are transported to several remote areas within the kingdom, also in recent years the kingdom started exporting temperature sensitive products to a lot of neighbouring countries in the Gulf and the volume of biopharmaceutical products are growing significantly.