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This workshop will explore how to develop and implement models of biological relevance using big data. The workshop will consist of two parts. In the first part, the focus will be on the development of mechanistic models, while the second part will look at using machine learning to create models from big data. Areas which are being targeted include pathway modeling, structural biology, systems biology, synthetic biology, and multi -omics analysis. The workshop will be interactive between the audience and the workshop leader, with the leaders providing case studies and/or demos.