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From its very beginnings over 70 years ago, simulation has been a powerful tool for assessing potential risks and guiding us in making decisions under uncertainty. The 2019 conference seeks to highlight the latest simulation technologies for more accurately anticipating risks and for making more robust decisions in the face of uncertainty, ambiguity, and variability. These include methods for robust and accurate simulation modeling, analysis, and optimization. We also invite papers describing applications of simulation to risk management in a broad variety of domains, including healthcare, disaster response, power grids, construction, transportation, finance, cybersecurity, and more.