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Integration of Immune and microbiome genomics, while in its infancy, is rapidly transforming Immunology research. A first of its kind meeting will bring together multiple pioneers and leaders who are merging genomics, immunology and microbiome research in making important discoveries in clinical and basic immunology. The meeting will include three days of extensive, interdisciplinary and informal discussions. Our aim is to create a forum and think tank enabling integration and sharing of knowledge in the emerging immuno-genomics field, hoping to define together the agenda of this new community for the next decade. The meeting will include presentation by over thirty invited speakers and of several selected abstracts, lively poster sessions, and many opportunities for interactions between leaders in basic research, pharma and the clinic.