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The International Symposium on Symbolic and Algebraic Computation (ISSAC) is the premier annual conference to present and discuss new developments and original research results in all areas of symbolic mathematical computation. All areas of computer algebra and symbolic mathematical computation are of interest. These include, but are not limited to: Algorithmic aspects: - Exact and symbolic linear, polynomial and differential algebra - Symbolic-numeric, homotopy, perturbation and series methods - Computational algebraic geometry, group theory and number theory - Computer arithmetic - Summation, recurrence equations, integration, solution of ODEs PDEs - Symbolic methods in other areas of pure and applied mathematics - Complexity of algebraic algorithms and algebraic complexity Software aspects: - Design of symbolic computation packages and systems - Language design and type systems for symbolic computation - Data representation - Considerations for modern hardware - Algorithm implementation and performance tuning - Mathematical user interfaces Application aspects: - Applications that stretch the current limits of computer algebra algorithms or systems, use computer algebra in new areas or new ways, or apply it in situations with broad impact.