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We are pleased to announce the 6th International Biennial Meeting of Human Variome Project Consortium (HVP6) will again be held at UNESCO headquarters in Paris. This biennial meeting will provide updates on the achievements of the past two years and time for discussion on the plans for the next two years of activities. HVP6 will bring together some of the most prominent professionals from around the world who address the many aspects of human genetics. You are encouraged to explore and share knowledge on data sharing, interpretation of unknown variants, collaboration between developing and developed countries, opportunities for the global collection, curation, and much more.