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This FASEB Science Research Conference will bring a greater understanding of the biochemical and molecular mechanisms underlying diseases associated with dysfunction in the neuroimmune system will undoubtedly facilitate the translational aspect of this field as novel therapeutic targets are moved towards human clinical trials. This will be facilitated by cutting-edge talks from scientists with international reputations on the topics of 1) CNS Metabolism and the Microbiome; 2) Inflammation in the Peripheral Nervous System; 3) Stem Cells and Neuroinflammation; 4) Neuroinflammatory Mechanisms of Demyelinating Diseases; 5) Immunity and Neurodegenerative Diseases; 6) Pre-clinical Studies for CNS Neuroinflammatory Diseases; 7) Neuroinflammation and Neurotrauma; 8) Neuroinflammation and Host Defense; and 9) The Many Faces of Microglia. In addition, this SRC will host a pre-meeting workshop entitled