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This FASEB Conference focuses on the interactions between obesity and immune cells, focusing in particular on how inflammation in various organs influences obesity and obesity-related complications. Obesity, insulin resistance, and type 2 diabetes have increased at epidemic proportions over the past several decades. In this context, the organizers have brought together a wide and diverse range of leaders in the fields of immunology, inflammation, and obesity, to share their latest findings on this evolving field. Individual sessions will focus on the separate roles of adaptive and innate immunity in immunometabolism; how obesity affects inflammation in organs such as the gut, the brain, and the liver; how inflammation develops with aging, and how it resolves; and how obesity-related inflammation promotes cancer. There will be opportunity for poster presentations and social and recreational activities, to promote discussion and networking amongst attendees, including students and post-doctoral fellows.