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This FASEB Science Research Conference focuses on new developments in the biology of lipid signaling with an emphasis on cancer, neuronal and cardiovascular diseases. The emphasis will be on molecular, cellular, structure/function and enzymatic mechanisms of physiological signaling pathways and how defects in these pathways contribute to the biology and pathophysiology of cancer, neurodegeneration and cardiovascular disease.The 2016 meeting brings together a wide range of leading investigators from across the globe. The scope of their subjects is vast, encompassing studies at the level of single proteins as well as the pathophysiology of complex disease. The program will highlight inter-disciplinary approaches and how major advances in biophysical, proteomic, genomic, imaging, modeling and therapeutic approaches are driving the field. The discussion forums and recreational activities will provide all participants extensive opportunities to exchange new ideas and forge new collaborations in a supportive interdisciplinary environment for participants at all stages of their research profession.