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On 3-7 September 2016 the Dutch Techcentre for Life Sciences and the BioSB research school will jointly organise the fifteenth edition of the European Conference on Computational Biology which will take place in the historic city of The Hague in the Netherlands. ECCB 2016 is the main computational event in 2016 and will welcome scientists working in a variety of disciplines, including bioinformatics, computational biology, biology, medicine, and systems biology. Participating in ECCB 2016 will be the perfect opportunity to keep pace with cutting edge research, and to network with members of ECCB community. This years European Conference on Computational Biology will be organized by the Dutch Techcentre for Life Sciences and the BioSB research school in association with the VU Amsterdam and the Delft University of Technology. The conference is supported by the municipality of The Hague.