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CCA 2016 is devoted to the advancement of Combinatorial Chemistry. Combinatorial Chemistry comprises chemical synthetic methods that make it possible to prepare a large number (tens to thousands or even millions) of compounds in a single process. These compound libraries can be made as mixtures, sets of individual compounds or chemical structures generated in silico. Combinatorial Chemistry can be used for the synthesis of small molecules and for peptides. Strategies that allow identification of useful components of the libraries are also part of Combinatorial Chemistry. The scope of CCA 2016 covers both theoretical and practical areas of Combinatorial Chemistry