Stabilizing dysferlin-deficient muscle cell membrane improves muscle function: In experimental model of LGMD2B, vamorolone improves and prednisolone worsens myofiber repair

In a head-to-head trial between the conventional glucocorticoid, prednisolone, and a modified glucocorticoid, vamorolone, in experimental models of LGMD2B, vamorolone improved dysferlin-deficient muscle cell membrane stability and repair. This correlated with increased muscle strength and decreased muscle degeneration, according to a new study.

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