Supercoil me! The art of knotted DNA maintenance: Supercoiling can keep DNA knots locked in place for long enough that they can be untied by specialised enzymes, a new study sayswww.sciencedaily.com

Locking DNA knots in place thanks to DNA propensity to be supercoiled. A new study suggests that is one of the mechanisms that could be harnessed by the cellular machinery to deal with those accidental entanglements that can compromise DNA functionality.

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