Sweet! How C. difficile toxin A enters intestinal cells: CRISPR/Cas9 genetic screen reveals the entry portal, and a potential treatment strategy

Clostridiodes difficile infection has become a leading cause of severe, sometimes fatal diarrheal illness, with the bacterium's toxins causing the damage. New work cements our knowledge of how C. diff's two primary toxins, A and B, slip into intestinal cells, the first step toward a possible treatment that doesn't involve antibiotics. This latest study, on toxin A, shows its activity can be blocked with molecules already being developed for various medical..