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During HIV infection, antibody can block B cells from fighting pathogens: NIH scientists suspect process aims to curb immune-system hyperactivity

During HIV infection, antibody can block B cells from fighting pathogens: NIH scientists suspect process aims to curb immune-system hyperactivity

For the first time, scientists have shown that in certain people living with HIV, a type of antibody called immunoglobulin G3 (IgG3) stops the immune system's B cells from doing their normal job of fighting pathogens. This phenomenon appears to be one way the body tries to reduce the potentially damaging effects of immune-system hyperactivity caused by the presence of HIV, according to the investigators, but in so doing, it also impairs normal immune funct..

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