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As digital computing and communication becomes faster, cheaper and available in packages which are smaller and use less power, these capabilities are becoming embedded in many objects and structures in the physical environment. Cyber-physical systems (CPS) are physical and engineered systems whose operations are monitored, coordinated, controlled and integrated by such computing and communication. Broad deployment of cyber-physical systems is transforming how we interact with the physical world as profoundly as the world wide web transformed how we interact with one another, and harnessing their capabilities holds the possibility of enormous societal and economic impact.