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The 53rd Annual Conference on Information Sciences and Systems will be hosted by the Johns Hopkins University Whiting School of Engineering’s Department of Electrical and Computer Engineering and a Technical Co-Sponsorship with IEEE Information Theory Society on March 20-22-2019. Authors are invited to submit previously unpublished papers describing theoretical advances, applications, and ideas in the fields of Information Sciences and Systems including Information Theory, Signal Processing, Communications, Energy Networks, Image Processing, Signal Processing, Coding, Systems and Control, Information in Health and Medicine, Photonic and Quantum Systems, Machine Learning, Security and Privacy, Statistical Inference, Sensory Systems, and Neuroscience.