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This course provides the active intermediate-to-advanced clinician with a comprehensive review of the science of HIV and HCV as well as updates on the application of HIV and HCV therapies. For ambitious newer clinicians who want a challenge, we will still offer our New Clinicians’ Track (NCT), which provides five additional lectures that cover antiretroviral therapy (ART); basic pharmacology, ART resistance, and the topic of IRIS and opportunistic infections. The course lecturers are leading clinicians and researchers who are also dedicated to teaching in their areas of expertise. Dr. Diane Havlir will frame the conference in the opening plenary with her keen take on the ‘Top Ten Issues’ in HIV medicine. Dr. Deeks will share the progress we have made toward a cure for AIDS. Dr. Susan Buchbinder will provide the underpinnings of prevention efforts and explore future efforts, followed by Drs. Susa Coffey and Jonathan Volk, who will highlight the clinical expansion of appropriate and successful RAPID and PrEP administration. Days 1 and 3 will be filled with important teachings in regard to effective administration of ART beginning with Dr. Monica Gandhi-s talk on the ‘State of the Art of Antiretroviral Use’ followed by a lively panel style debate on appropriate ART choices. Dr. Peter Chin-Hong will join the faculty this year and discuss the role of Immune Modulators in HIV Medicine and Dr. Laurence Huang’s update from the HIV Chest Clinic will complete Day 1. Day 2 begins with Dr. Annie Luetkemeyer leading the expanded Hepatitis section followed by Dr. Jenny Price who will answer our most complex liver questions. We will continue our Friday small group sessions dedicated to HCV treaters with separate beginner and advanced sessions and a joint pharmacology session taught by Dr. Parya Saberi. These case-based formats will address the issues that arise in the care of chronically infected patients including the safe administration of new, even more efficacious therapies. Effective treatment of drug and alcohol issues is critical to our patients’ health. Drs. Kathleen Grieco and Paula Lum will address the exciting evolution of available therapies for these issues. Dr. Deb Cohan will update us on “HIV Reproductive Health for Women and Men” and Dr. Toby Mauer will cover “HIV Dermatology”. Small groups sessions will occupy the remainder of Day 2. On Day 3 we will continue to explore how to manage complications common in HIV medicine, with Dr. Vivek Jain speaking on hyperlipidemia, Dr. Madeline Deutsch on ‘Transgender Health’ while STI’s will be discussed by Dr. Susan Philip. Dr. Jagannathan will continue to address essential issues that impact ‘Well-being and Health’. In the afternoon on Day 3, you-ll be able to privately test your antiretroviral judgment and compare your clinical choices to those of the master clinicians on our ART panel led by Dr. Oliver Bacon. Dr. Lisa Murphy will complete the conference with another notable talk on HIV Endocrinology. Primary Care topics will be woven throughout the course and this 3-day conference will provide the breadth and depth of topics relevant to the field of HIV Medicine. The HIV, ID and Global Medicine Division, Zuckerberg San Francisco General Hospital and Trauma center, Department of Medicine, University of California, San Francisco, and the School of Medicine present this symposium. TARGET AUDIENCE Designed for practicing clinicians, including family practitioners, internists, infectious disease specialists, physician’s assistants, and nurse practitioners, this course will focus on the practical issues in the care of patients at all stages of HIV/AIDS and infectious Hepatitis C.