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The goal of the Gordon Research Seminar on Muscle: Excitation-Contraction Coupling is to bring together students, postdocs and other early career researchers who share an interest in EC Coupling science. The GRS is organized by early career scientists and designed to promote the exchange of specialized expertise and discuss innovative results in a welcoming and relaxed environment. This interaction is necessary to create fruitful collaborations and most importantly, to push beyond our current understanding of muscle physiology and pathophysiology. The 2019 Muscle EC Coupling GRS will integrate the latest cutting-edge concepts and approaches to studying EC coupling from the field’s junior investigators. The program will encompass a range of topics related to EC coupling, including structure/function of ion channels, regulation of compartmental calcium handling and mechanisms of pathophysiology in muscle disease. This two-day meeting will consist of four sessions; starting with a Keynote Lecture, presented by Dr. Susan Treves from University Hospital Basel, Switzerland - a distinguished EC coupling scientist with experience in basic and applied research. The two Scientific Sessions will be the core of the program, consisting of oral presentations and poster sessions. Speakers and session chairs will be selected from abstracts submitted by early career scientists The last session will be the Mentorship Component, which will give attendees the opportunity to seek advice on issues such as funding success and transitioning to the next stage of your career from a panel of established scientists.