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Protein science has undergone revolutionary changes in the last decade. Vast amounts of genomic information inform our analyses of protein biology, structure, and function. The elucidation of high-resolution molecular structures has become almost routine, while new technologies provide unprecedented insight into mechanistic details, molecular assemblies of increasing complexity, and views of processes as they occur in living cells. Advances in experimental methodology have been mirrored by advances in computational approaches and together the two are providing unprecedented insight into dynamics and mechanism. The 2019 Proteins Gordon Research Conference and will bring together experimental, theoretical and computational biochemists, biophysicists, chemists, chemical biologists, biologists and bioengineers who study the diverse aspects of protein science including protein function, dynamics, regulation, folding, and evolution. Recent exciting advances and the strong history of this meeting promise to provide an outstanding conference experience for participants at all career stages. Invited speakers will highlight a wide range of approaches for addressing critical and emerging problems in protein research. Numerous speaking opportunities are reserved for young investigators and for late-breaking results presented in short talk slots and "poster preview" talks in the GRC, as well GRS talks. Poster sessions provide additional venues for broad dissemination of participants- research and deeper discussions of research findings. The GRC and accompanying GRS are meeting in the relaxed, beautiful setting of the White Mountains at Holderness, New Hampshire. Through collegial formal sessions, lunchtime round table discussion themes, poster sessions, social events, and afternoon recreational activities, ideas will flow freely between sub-disciplines and generations.