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We are very pleased to welcome you in Ghent for the XVIII International Conference on Heterocycles in Bioorganic Chemistry (Bioheterocycles 2019) from June 17 to 20, 2019. The Bioheterocycles conference, initiated in 1980 by Prof. Henk van der Plas, is a biennial meeting in Europe, focusing on the synthesis and biological activities of heterocyclic compounds. The objective is to provide an informal meeting, facilitating fruitful interactions between young scientists, established academics, recognised international speakers and industrial experts on emerging trends and new developments related to heterocycles in chemistry, biology, medicine, agriculture,… Ghent-s city center is a pedestrian area that is like a museum on early Flemish architecture and a testament to the city-s rich medieval history. A walk through the town on a summer-s evening, when most of the important buildings are illuminated, is an unforgettable experience, as is a boat trip on the many branches of the Scheldt and Leie canals that intersect the city. Get lost in the historic center, explore the museums, enjoy the culinary talent and local beers, or throw yourself into the bustling nightlife. The conference venue (“Het Pand”) is located in the heart of the city, close to many hotels, restaurants, bars, shops and the historic center. Furthermore, travel to Ghent is easy because of a direct and frequent train connection between the Brussels International Airport building and the city center.