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The Cell Biology of Metals Gordon Research Seminar is a unique forum for graduate students, post-docs, and other early career scientists with comparable levels of expertise and education to present and discuss new cutting edge research and ideas regarding the roles of metals within cells. The 2019 GRS will build off the success of the original 2017 seminar by providing a welcoming and inclusive environment that encourages attendees to develop new collaborations, conceive novel ideas and foster networks with peers and mentors before the start of the GRC. A cornerstone of the Cell Biology of Metals GRC is bringing together a broad range of researchers to bridge the gap between basic and applied research with metals. This GRS also encourages applicants from all the interdisciplinary fields within metal-based cell biology research to apply and participate in the GRS. The 2019 GRS will feature several sessions with short talks being selected from posters and abstracts. The theme of this year’s GRS is uncovering mechanisms by which living organisms support metal protein speciation, with a focus on metal sensing and trafficking in homeostasis, mechanisms of metallo-cofactor and metalloenzyme biogenesis, structure-function relationships in metalloproteins, metal-mediated natural selection, nutritional immunity, and aberrations in handling the metals of life. The 2019 GRS will also include a career/networking panel to allow students to gain valuable knowledge from tenured faculty and industry experts about how to foster and retain professional networks as well as discovering unconventional careers for PhDs. This interactive networking session is aimed at providing trainees with the knowledge, strategies, and skills necessary for navigating and maximizing their experience at the GRC, and being successful both inside and outside of the academic setting.