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The Cellular and Molecular Mechanisms of Toxicity GRC is a forum for showcasing the latest unpublished and innovative advances in mechanistic toxicological research and its translational application to safety assessment, risk management and public health policy. The program highlights innovations and challenges in mechanistic toxicology including the human exposome, big data and quantitative systems modeling, translational medicine and target organ toxicity, microphysiological systems, nuclear receptor targeting, and emerging technologies and alternative methods in risk assessment. Highlighted speakers have been selected to represent diverse perspectives on environmental, industrial, and pharmaceutical toxicology with a special session spotlighting rising young investigators. A distinctive "Power Hour" event will discuss the challenges women face in sciences, mechanisms to support their professional growth and offer an opportunity for feedback and professional advice from peers and leading mentors in an informal atmosphere. Daily poster sessions will provide participants the opportunity to present their latest, unpublished work in an atmosphere that fosters a relaxed dialog and idea sharing. A select number of abstract submissions will also be chosen for "late-breaking" short oral presentations. A key to the success of the GRC format is the networking opportunities that occur at meal times and during daily social/recreational activities. These exchanges have often led to long-lasting scientific collaborations, connections and career opportunities. A Gordon Research Seminar (GRS) will precede this GRC conference. The GRS is organized and run by graduate students and fellows. It provides an expanded opportunity for trainees and young scientists to be exposed to cutting-edge science and to network with their future colleagues. All GRS attendees are also encouraged to apply to this GRC conference.