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Heterocyclic compounds are an integral feature in modern chemical science. They are foundational in their ability to inspire the development of novel synthetic methods and strategies. Their representation in complex molecule architectures presents unique and intriguing challenges that demand original solutions. Heterocycle units also serve crucial functions; for instance, they can establish the optimal structural and electronic characteristics to engender a targeted biological response. The heterocyclic compound exists as a connective thread, bringing together innovators in catalysis, medicinal and biological chemistry, synthesis, and materials science. At the 2019 Heterocyclic Compounds GRC, we will see an array of presentations signifying the state-of-the-art in heterocycle chemistry. Cutting-edge presentations from domestic and international leaders in total synthesis, catalysis, methods development, bioorganic chemistry, and pharmaceutical science will comprise the week, reflecting the contemporary problems and ingenious solutions that our field provokes. An impressive slate of poster presentations will highlight additional advances in heterocycle science. The coastal campus of Salve Regina in beautiful Newport provides an excellent setting for stimulating scientific discussions. We hope you will join us at the GRC for what promises to be one of the most exciting chemistry conferences of the year.