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This conference will be the first digital health meeting that focuses specifically on the scientific foundations and health applications of digital technologies. Taking a novel sensor or new device from concept to clinic is remarkably complex, and the technologies are evolving rapidly. Digital technology offers novel capabilities that have great potential to drive chronic disease understanding and management at both an individual and population level, including the ability to deliver real-time interventions that can be connected to a healthcare system, in a community setting or in limited-resource settings. The increased use of digital capture devices has become a universal part of everyday life; however, more research is needed to provide evidence that wearables and even more sophisticated implantable medical devices will transform healthcare delivery quality and costs.