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This conference will address fundamental questions of the biology of the malaria parasite, its vector, the (immune) response of the host and the disease that it causes, and will showcase the latest technological approaches. The use of “big data” and computational approaches to tackle fundamental biological questions will be assessed. This will be the 15th BioMalPar conference at EMBL Heidelberg. The conference series has built on the success of the EU funded Networks of Excellence EviMalaR and BioMalPar and, for more than a decade, has brought together malaria researchers from Europe with their colleagues and collaborators from around the world, to present and share recent ground-breaking findings on fundamental malaria research in an integrated and highly collaborative environment.