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The Gordon Research Seminar on Nucleic Acids is a unique forum for graduate students, post-docs, and other early career scientists with comparable levels of experience and education to present and exchange new data and cutting-edge ideas regarding all aspects of the biology and chemistry of Nucleic Acid. This seminar provides an exceptional opportunity to build scientific insight and peer networks in a supportive environment before attending the larger GRC meeting. Attendees will have access to mentorship and career advice from experts in academia and industry. The format of the GRS allows ample time to not only highlight recent advances in nucleic acid biology and chemistry, but also an atmosphere for fruitful scientific discussion, interactions and the exchange of new ideas. Topics of the 2019 Nucleic Acids GRS will include organization, regulation, structural insights, and mechanistic details across a wide range of nucleic acid biology, in addition to recent advances in RNA and DNA applications and technologies. The program will include three platform sessions with a total of 10-15 talks selected from abstracts, and two poster sessions. Sessions will be chaired by selected students/postdocs.