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Intercellular and matrix adhesion collectively define the physical and molecular signaling interface between cells and their environment. Beyond simple glue-like functions, adhesion receptors play key roles in regulating proliferation, migration, differentiation, and essential aspects of the signaling state of the cell. The 2019 Cell Contact and Adhesion Conference will feature the latest results in cell adhesion biology, utilizing the full diversity of cutting edge methods in cell and molecular biology, biochemistry, engineering, and biophysics. There will also be several talks featuring fundamentally new functions for adhesion in regulating tissue level biology in both development and disease states.