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The major goal of the 2019 Myogenesis Gordon Research Conference is to broaden our current knowledge on the cellular and molecular mechanisms that control the formation, the maintenance and the regeneration of skeletal muscle. The program aims to cover the latest advances in a variety of topics including: Building and maintaining skeletal muscle; The complexity of skeletal muscle architecture; Extrinsic regulation of the muscle microenvironment; The complexity of skeletal muscle architecture; Satellite cells and regeneration; Intrinsic signaling in muscle cells; Epigenetic, transcriptional, post-transcriptional regulation of myogenesis; and Cellular and molecular mechanisms of muscular diseases. Leaders in the field will present recent unpublished data on these topics to educate conference attendees while stimulating interactive discussion amongst the group. The program will provide opportunities for platform presentations from young emerging leaders in the field through both “invited speaker” and “abstract-selected talk” mechanisms. Additional program events, including poster sessions, poster teasing, specific social events and informal gatherings in the afternoons, will ensure maximal level of interaction between established scientists and junior scientists/trainees. The venue of the conference in Italy’s Tuscan mountains offers a relaxing atmosphere conducive to creative thinking and the exchange of ideas that will benefit attendees at every professional level. Thus, we expect the 2019 Myogenesis Gordon Research Conference will provide an ideal scenario for attendees to advance their understanding of skeletal muscle biology.