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This EMBO Practical Course will cover a range of genome analyses and their fundamental elements. The first principal theme of the course is comparative genomics, covering genome analysis and exploration, pair-wise and multiple comparisons of genomes and evolutionary inferences (orthologs, paralogs and their classification). The second principal theme of the course is related to Next-Generation Sequencing data analyses, including sequence assembly methods, metagenomics and its applications as well as genomic structural variants. The main objectives of this EMBO Practical Course are to strengthen skills of students in genomics and bioinformatics on the use of algorithms, key software, statistical and visualization methods, and their various applications in genome studies. The course program is designed to provide a solid theory class followed by practical sessions on each topic, where the same speaker will deliver at least one half-day course of theory and practice. Students will obtain the dexterity to manipulate large data sets in a Unix environment and a basic understanding of scripting and programming skills. Students are assumed to be familiar with the Unix environment. Similar course programs and organizations can be found at this link. Who can attend the EMBO Practical Course: This EMBO Practical Course is aimed at motivated PhD students and young researchers from academic Institutions with a background in Mathematics, Statistics, Computing, and/or Biology who are involved in bioinformatics and genome analyses projects. This course is intense; therefore active participation is expected from the students.