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The 2019 Gordon Conference on Mechanisms of Membrane Transport will continue the tradition of integrating structure, dynamics and function to reveal the mechanisms of membrane transporters and channels. This year, the Conference will further emphasize an integrative view of transport proteins as part their environment, where they are synthesized, fold and function within lipid membranes and where they evolve to fulfill the needs of cellular metabolism and signaling. The program will be grounded in the transformative recent structural advances and will cover novel means to experimentally and computationally probe protein energetics, dynamic and biogenesis. The Conference has always made an explicit effort to provide a platform for young scientists to present and discuss their work. The program will include talks from both established and early career researchers and there are a number of speaking slots reserved for selection from submitted abstracts by students and postdocs. Daily poster sessions will provide extensive opportunities for in-depth scientific discussion. Following the newly established tradition, a Gordon Research Seminar (GRS) on the Mechanisms of Membrane Transport will be held immediately prior to the Conference, building on the successful Seminars of the prior two years. The Seminar, organized by the trainee scientists, will provide an additional forum to highlight research and to network as well as to discuss challenges of the early career stages. We strongly encourage Conference applications by both junior and senior scientists from overseas, by minorities, and those with disabilities, and we are applying for funds to support some costs of those with financial constraints.