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The inaugural 2019 Gordon Research Seminar on Genome Architecture in Cell Fate and Disease is a unique forum for graduate students, postdocs, and other junior scientists to present and exchange new data and cutting-edge ideas. This meeting will explore recent advances in genome architecture with a focus on chromatin biology, epigenetic inheritance, and the regulation of gene expression. We particularly encourage those working in model organisms, embryonic development, or in human disease to attend. To enhance the discussion of these topics, the GRS will include a Keynote address from Dr. Peter Fraser whose work has contributed significantly to this field. Additionally, attendees will have the opportunity to attend a session focused on career advice from panelists in academic and non-academic fields. The main goal of the Genome Architecture in Cell Fate and Disease GRS is to provide opportunities for early career and young attendees to interact with their peers as well as with established investigators in the field. We aim to foster the exchange of novel ideas, diverse interactions and long-lasting collaborations. Early-stage scientists will have the opportunity to present their work and obtain feedback from colleagues and experienced scientists, enabling them to build on their work and potentially explore novel ideas. Attendees will have a chance to hear about the experiences of scientists at various career stages and explore additional opportunities for professional development. We expect the scientific interactions at the GRS to carry over to the main conference to make it an even more enriching experience for all attendees.