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The 2019 Gordon Research Conference titled "Wnt Signaling Networks in Development, Disease and Regeneration” will bring together a diverse group of scientists from around the world with expertise in developmental and stem cell biology, evolution, biochemistry and biophysics, structural biology, cancer research and medicine. Wnt signaling is a highly conserved developmental signaling pathway with pivotal roles in the origin and evolution of all metazoans. Meeting sessions will cover a broad spectrum of biological systems and methodologies with the goal of advancing our understanding of the complex and highly conserved Wnt signaling pathway.