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The Banff International Research Station will host the "Next Stages Toward a Comprehensive, Integrated Framework for Advanced Statistical Analyses of Observational Studies" workshop in Banff from June 2 to June 7, 2019. We are entering the era of automatically collected big data, whose amount and complexity create serious analytical challenges. Novel developments in the methodology of statistical analysis and implementation of user-friendly software are essential to maximize the potential of such data to gain deeper understanding into complex, dynamic, multi-stage, multi-facet processes affecting human health, economy or environment and, ultimately, extend the duration and improve the quality of human lives. This workshop is unique in bringing together statistical experts from across the world, whose joint expertise is essential to address the multiple, inter-twined analytical particular challenges from the structure and complexity of large databases analyzed in empirical sciences. The workshop will build on the achievements of our 2016 BIRS workshop, by providing a systematic update on recent progress in development and systematic evaluation of novel statistical methodology in many areas essential for the analysis of observational population-based studies. The participants will also identify complex outstanding issues that require further analytical research, and devise strategies to tackle these challenges. To maximize its impact on both international statistical research community and the actual analyses of data collected in different fields of science, the workshop’s results will be systematically disseminated, through publications and the website of the recently started STRATOS initiative (http://stratos-initiative.org/), a worldwide cooperation of leading researchers in statistics. The Banff International Research Station for Mathematical Innovation and Discovery (BIRS) is a collaborative Canada-US-Mexico venture that provides an environment for creative interaction as well as the exchange of ideas, knowledge, and methods within the Mathematical Sciences, with related disciplines and with industry. The research station is located at The Banff Centre in Alberta and is supported by Canada-s Natural Science and Engineering Research Council (NSERC), the U.S. National Science Foundation (NSF), Alberta-s Advanced Education and Technology, and Mexico-s Consejo Nacional de Ciencia y Tecnología (CONACYT).