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The 2019 Spring Simulation Multi-Conference will feature the 27th High Performance Computing Symposium (HPC 2019), devoted to the impact of high performance computing and communications on simulations. Advances in novel and heterogeneous architectures, high-end computers, large data stores are ushering in a new era of high performance parallel and distributed simulations. Along with these new capabilities come new challenges in computing and system modeling. The goal of HPC 2019 is to encourage innovation in high performance computing and communication technologies and to promote synergistic advances in modeling methodologies and simulation. It will promote the exchange of ideas and information between universities, industry, supercomputing centers, and national laboratories about new developments in system modeling, high performance computing and communication, scientific computing as well as simulation.