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ECI’s Integrated and Continuous Biomanufacturing Conference (ICB) is the world’s premiere conference in the area of continuous biomanufacturing. It accepts only the highest-quality scientific papers. No commercial entities influence the scientific programming. Integrated and continuous biomanufacturing is being implemented across the biopharmaceutical industry. It is a powerful process intensification tool enabling cost-effective, lean, and agile manufacturing facilities. The development of these technologies has been discussed in our past conferences ICB I (2013), ICB II (2015), and ICB III (2017).