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Since 2009, this bi-annual FASEB Science Research Conference (SRC) has alternated between the U.S. and Europe. It brings together experts from the fields of sirtuins, poly(ADP-ribose) polymerases (PARPs), calcium signaling, transcription, mitosis, immunology, and cancer with those specializing in drugs and nutritional interventions that interface with the fundamental and translational science of NAD+. It is the only scientific meeting that cuts across all these areas.