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This workshop, sponsored by AIM, the Simons Foundation, and the NSF, will consider the role of topology in characterizing materials and in the prediction of their physical properties, particularly for two-dimensional material such as graphene. The focus will be on important mathematical questions at the interface of the analysis and topology in the context of the governing fundamental partial differential equations and other models. Two such questions are the bulk edge correspondence and the existence and robustness of edge states in aperiodic settings.