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SPIRE 2019 is the 26th International Symposium on String Processing and Information Retrieval. SPIRE started in 1993 as the South American Workshop on String Processing and was held in Latin America until 2000 when SPIRE travelled to Europe and was held A Coruña, Spain. Nineteen years have gone, and SPIRE is back to Spain, this time allowing attendees to visit Segovia, a beautiful historical city located very close to Madrid that was declared World Heritage City by UNESCO in 1985.