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Mathematical models of scientific applications often involve simulations with a large number of degrees of freedom that strain even the most efficient of algorithms. A clear need is the rigorous development of models with reduced complexity that retain fidelity to the application. Mathematics-based reduced-order modeling applies techniques in nonlinear approximation, projection-based discretizations, sparse surrogate construction, and high-dimensional approximation, in order to construct a model surrogate with near-optimal approximation properties. This workshop focuses on theoretical and algorithmic advances in mathematics-based model order reduction of various types: reduced basis methods, projection-based methods for dynamical systems, and sparse and low-rank approximations in high dimensions.