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SPEC 2020 is the 11th conference in the successful SPEC series, providing an occasion to both look back at the past two decades and to look forward at the next decade of translating vibrational spectroscopies into the clinic. SPEC 2020 will bring together research scientists and clinicians, from industry, academia, and medicine, to highlight and discuss recent advances in developing novel spectroscopic instrumentation and technologies to improve health and patient outcomes.