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The Gordon Research Seminar on Diffraction Methods in Structural Biology is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. Macromolecular crystallography is experiencing a revolution in the rate of data collection. This has been enabled through innovations in fast readout detectors, extensive beamline automation, and the development of more advanced sources such as XFELs. Serial crystallography, time-resolved studies and dynamics, and micro electron diffraction are harnessing these developments to generate an unprecedented amount of data. As gigabyte and even terabyte-sized datasets become more common, high performance data storage and new methods to automate data processing will be paramount in the standard workflow. This seminar will highlight experiments already producing large datasets and methods facilitating fast and efficient protein structure solution. We also ask the question: what new biological systems could be the next great structural challenge given this data-rich revolution?