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The Gordon Research Seminar on Biology of Acute Respiratory Infection is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. Because maintenance of lung function is critical to life, both pathogens and the host must balance immunity and inflammation in order to survive. The focus of this meeting is how this balance affects acute lung infection, including through polymicrobial infections, the microbiome, environmental effects, immune tolerance, and anti-microbial and immune supporting therapies.