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The 2020 Gordon Research Conference on Biointerface Science brings together scientists and thought-leaders, from students to senior investigators, in the rapidly moving field of biological interfaces, both natural and engineered. Biointerface Science encompasses the chemistry and physics of cellular membranes and their associated molecular assemblies, signal transduction and biological information processing, and the spatial organization of biological components. The GRC will explore this fundamental science along with its applications in areas such as cellular communications, signaling mechanisms, and synthetic responsive systems. During the week, we will identify new scientific and technological opportunities associated with the biointerface field and provide an open forum for debate and discussion.