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The Gordon Research Seminar on Cyclic Nucleotide Phosphodiesterases is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience to present and exchange novel data to the field. This meeting will be a journey from the underpinning basic science of PDEs through to the mapping of PDE pathways and investigations into the resulting functional impacts. Furthermore, it will explore recent progress made in identification and development of both new and established therapeutic targets modulating cyclic nucleotide signalling. The key focus of this seminar will be on highlighting newly discovered fundamental insights that will increase our knowledge of the role of PDEs. Unique to the GRS is that the meeting will also feature a mentorship session which provides an opportunity for informal discussions on career aspects and development with both academic and industry experts.