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This course will focus on case-based and didactic presentations from Mayo Clinic and other international experts in the treatment of the whole spectrum of gastrointestinal (GI) cancers including esophageal, gastric, hepatocellular, pancreatic, small bowel, bile duct, anal and colorectal and gallbladder. The primary goal of this course is to guide practicing physicians on integrating the best and most current evidence into their day-to-day routine care for patients with GI cancers. This course will also bring a practical perspective on how to optimize multidisciplinary care for some of the more complex clinical management decisions. Topics discussed will include: locoregional modalities, the role of minimally invasive procedures and state-of-the-art radiation modalities.