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Extracellular vesicles (EVs), which are generated by almost all living cells, are now considered to be an important system of cell–cell communication. A large volume of data has been published on EVs in different fields of biology and medicine, from immunology to marine biology. These data are discussed at large international meetings that gather thousands of researchers. However, there is still a need for more-focused meetings at which the importance and reliability of the data should be evaluated by a narrow circle of experts. Here, we propose to organize a small conference that will focus on one of the most important aspects of EVs, their role in infectious human diseases. The aim of the proposed conference is to improve our understanding of the mechanisms of this involvement and to evaluate EVs as potential therapeutic targets.