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The quality of life in gynecology means to deal with ageing of intimate zone, childbirths, changes of skin conditions. Quality of life is becoming a major demand of women and intimate well-being is also crucial. Intimate rejuvenation is getting a high demand worldwide since the last ten years and the market is expected to grow widely in the future. Expansion of indications comes together with more effective treatments and medico-surgical techniques reinforcing the trend towards natural aspect. Combined treatments provide also better and less invasive results. The first check-up consultation is essential to diagnose specific disorders that need specific treatments, to orient to the correct specialist whenever required, to point any contraindications in the intimate rejuvenation treatments planned. Holistic approach do involve several doctors and allied health professionals, then needs to build multidisciplinary network. Integrative tools and standardized follow-up are helpful to make objective analysis and make a treatment plan.