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The purpose of the International Symposium on Mathematical and Computational Oncology (ISMCO) is to provide a common interdisciplinary forum for mathematicians, scientists, engineers and clinical oncologists to present and discuss the latest research findings, ideas, developments and applications in mathematical and computational oncology. In particular, ISMCO aspires to enable the forging of stronger relationships among mathematics and physical sciences, computer science, data science, engineering and oncology with the goal of developing new insights into the pathogenesis and treatment of malignancies. The symposium will consist of invited and contributed presentations (oral and poster) dealing with all aspects of mathematical and computational oncology. There will also be several keynote presentations, tutorials, special tracks, and panel discussions.